A benefit from treatment that relates to an important outcome, such as length of life, and is large enough to have practical importance to patients and health professionals. Effects that are identified as statistically significant are not always clinically significant, because the effect is small or on an outcome that is unimportant.

For example, a treatment may improve blood flow but for that condition, there is no evidence that this leads to an important clinical outcome, such as lower risk of blood clots or heart attack. HTAI

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